Glucoryl-M2 Tablet Uses, Side effects, Precautions

CompositionGlimepiride(2mg) + Metformin(500mg)
CompanyAlkem Laboratories Ltd.
Medicine typeAntidiabetic(Type 2 diabetes)
Route of administrationOral
prescription requiredYes

General uses of Glucoryl-M2 Tablet

Glucoryl-M2 Tablet is a combination of Two medicine. It is mainly used in the treatment of Type 2 Diabetes in adults.

This medicine helps to lower the blood glucose levels in diabetic patients.

Ingredients of Glucoryl-M2 Tablet

Glimepiride: Glucoryl-M2 Tablet contains Glimepiride(2mg). Glimepiride is a Sulfonylureas group of Anti-diabetic drugs. It helps in lowering the blood glucose levels in the body.

Metformin: Glucoryl-M2 Tablet contain Metformin(500mg). Metformin is a Biguanides group of Anti-diabetic drugs. It is generally prescribed with other anti-diabetic drugs to treat Type 2 diabetes.

How does Glucoryl-M2 Tablet work?/Mechanism of action

Glucoryl-M2 Tablet is a combination of two medicines. The Glimepiride in this medicine is a Sulfonylureas group of drugs. It works by binding to SUR1(sulfonylureas receptors) in beta cells and inhibits the k+ sensitive channels. This leads to the opening of Ca2+ channels and therefore enhances the Ca2+ influx. This leads to an increase in insulin secretion. Increase insulin secretion helps in lowering the blood glucose levels in the body.

While Metformin In this medicine is a Biguanide class of anti-diabetic drug. It does not cause any effect on insulin secretion like other diabetic drugs. Metformin works in different ways to lower the Blood sugar levels in the body. It works by:

  • Suppressing the hepatic gluconeogenesis and glucose output from the liver.
  • Decreasing Intestinal absorption of Glucose.
  • Improving Peripheral glucose utilization.

Side effects of Glucoryl-M2 Tablet

The Glucoryl-M2 Tablet may cause some side effects like:

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Hypoglycemia (low blood glucose level)
  • Metallic taste(taste change)
  • Headache

When to Avoid Glucoryl-M2 Tablet/Precautions

  • Pregnant women must avoid the use of the Glucoryl-M2 Tablet.
  • It is not safe to consume this tablet with the use of alcohol.
  • It is not advised to use Glucoryl-M2 Tablet for patients with severe kidney disease.
  • One who is hypersensitive to Glimepiride or Metformin should avoid the use of this tablet.
  • As this medicine is only used to treat Type 2 diabetes, It is not advised to use this medicine in Type 1 diabetes mellitus.

How to use Glucoryl-M2 Tablet

Take the dose of Glucoryl-M2 Tablet as advised by your doctor.

This medicine should be taken with the food or just before or after having a meal.

Do not chew, crush, or break the tablet. Swallow it as a whole.

Some FAQs

What is the best time to take the Glucoryl-M2 Tablet?

The best time to take this medicine Is with the food. You should take this medicine at the same time every day to get the most benefit.

What are the major side effects related to the Glucoryl-M2 Tablet?

Generally, the Glucoryl-M2 Tablet does not have any major side effects. But In some patients, it may show one major side effect known as lactic acidosis. The metformin in this medicine is responsible for lactic acidosis. But this is rarely seen in the patients.

Can I stop using Glucoryl-M2 tablet, when my blood glucose levels are controlled?

No, You should not stop the use of Glucoryl-M2 medicine, when your blood glucose levels are controlled. You should consult your doctor about this and only your doctor will tell you, whether to stop using this medicine or not.

Is it safe to take Glucoryl-M2 Tablet during pregnancy?

No, It is not safe to use this tablet during pregnancy

What are the uses of the Glucoryl-M2 Tablet?

The Glucoryl-M2 Tablet is an anti-diabetic medicine and is generally used in treating the Hyperglycemia(high blood glucose level). This medicine helps to lower the blood glucose(sugar) levels in the body.


The Glucoryl-M2 Tablet is a combination of two medicine i.e. Glimepiride and Metformin. It is generally used in the treatment of Hyperglycemia(a condition when the blood glucose levels in the body increase).

It helps to lower the blood glucose levels in the body. It is only advised to use in the treatment of type 2 diabetes.

Note: The above details about the Glucoryl-M2 Tablet is for informative and study purposes. Do not use this medicine without consulting to doctor or pharmacist.

Sahil Nasa (B. Pharma)
Sahil Nasa (B. Pharma)

Sahil is the founder of He likes to read books and write blogs.

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