Istamet 50mg/500mg Tablet Uses, Side effects, Precautions

Istamet 50mg/500mg Tablet uses, side effects, precautions

CompositionSitagliptin (50mg) + Metformin (500mg)
CompanySun Pharmaceutical Industries Ltd
Medicine TypeAntidiabetic
Prescription requiredYes
Route of administrationOral
UsesType 2 Diabetes Mellitus
Side effectsNausea, Abdominal Pain, Diarrhea
PrecautionsHypersensitivity, Alcohol

General uses of Istamet 50mg/500mg Tablet

Istamet 50mg/500mg Tablet is a combination of two medicines. It is generally used to control the blood sugar (glucose) level in patients with type 2 diabetes mellitus.

Sitagliptin and metformin in this medicine work differently to control both fasting and postmeal blood sugar level in the body.

Ingredients of Istamet 50mg/500mg Tablet

Sitagliptin: Istamet 50mg/500mg Tablet contain sitagliptin (50mg). It belongs to the class of medicines known as DPP-4 inhibitors. It generally works by increasing insulin secretion from the pancreas and helps control blood glucose levels.

Metformin: It contains metformin (500mg). Metformin belongs to the class of medications known as biguanides. It helps control blood glucose levels in patients having type 2 diabetes.

How does Istamet 50mg/500mg Tablet work? / Mechanism of action

Istamet 50mg/500mg Tablet is a combination of two medicines. Sitagliptin in this tablet works by inhibiting the DPP-4 (Dipeptidyl Peptidase-4) enzyme. Inhibiting the DPP-4 enzyme inhibits the inactivation of incretins (GLP-4 and GIP). This result helps GLP-4 and GIP to secrete more insulin from the beta cells of the pancreas and eventually helps control the blood sugar (glucose) levels in the body.

While metformin in Istamet 50mg/500mg Tablet works by:

  • Lowering the glucose output from the liver.
  • Decreasing intestinal absorption of glucose.
  • Improving the utilization of glucose in the body.

When Istamet 50mg/500mg Tablet is prescribed?

Istamet 50mg/500mg Tablet is usually prescribed in patients with type 2 diabetes mellitus to control the blood glucose levels.

Side effects of Istamet 50mg/500mg Tablet

Istamet 50mg/500mg Tablet may cause some side effects like:

  • Nausea
  • Abdominal Pain
  • Diarrhea
  • Loss of appetite
  • Dizziness
  • Headache
  • Hypoglycemia (low blood sugar level)

Precautions

Alcohol: It is not advised to take alcohol with this medicine.

Hypersensitivity: You should avoid using this medicine if you are hypersensitive (allergic) to any of the ingredients of Istamet 50mg/500mg Tablet.

Liver or kidney disease: This medicine should be used with caution in patients with any liver or kidney disease.

How to use Istamet 50mg/500mg Tablet?

Take the dose of Istamet 50mg/500mg Tablet as advised by your doctor.

It is best to take Istamet 50mg/500mg Tablet with the meal.

Do not chew, crush, or break the tablet. Swallow it as a whole.

Storage of Istamet 50mg/500mg Tablet

Store Istamet 50mg/500mg Tablet at room temperature.

Keep this medicine away from kids and pets.

Keep this medicine away from direct sunlight.

Tell your doctor if:

  • You are allergic to sitagliptin or metformin.
  • You’ve any liver or kidney disease.
  • You are taking some other antidiabetic medications.

Some FAQs

What are the uses of Istamet 50mg/500mg Tablet?

Istamet 50mg/500mg Tablet is a combination of two medicines. It is generally used to control the blood glucose (sugar) level in patients with type 2 diabetes mellitus.

What is the dose and duration of Istamet 50mg/500mg Tablet for adults?

For adults, Istamet 50mg/500mg Tablet is usually prescribed one tablet 1-2 times a day. But the dose and duration of this medicine are not the same for all and depend on various factors. You should always consult your doctor about the dose and duration of this medicine.

What are the side effects of Istamet 50mg/500mg Tablet?

Istamet 50mg/500mg Tablet may cause some side effects like nausea, vomiting, loss of appetite, abdominal pain, and hypoglycemia (low blood sugar level).

Summary

Istamet 50mg/500mg Tablet is an antidiabetic medicine that contains sitagliptin and metformin as its active ingredients. It is generally used to control the blood glucose level in patients with type 2 diabetes mellitus.

This medicine should be used with caution in patients with any liver or kidney disease.

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